SWD2 — Schizosaccharomyces pombe 972h-

Summary

SPAC824.04 (SWD2) on chromosome 1 of Schizosaccharomyces pombe encodes an uncharacterized WD repeat-containing protein belonging to the Swd2/WDR82 family, characterized by WD40 repeats. The protein is associated with chromatin binding and localizes to the nucleus, cytosol, chromatin, telomeric regions, the Set1C complex, and the mRNA cleavage and polyadenylation specificity factor complex. It is linked to regulation of chromatin silencing at centromeres, heterochromatin island assembly, telomeric silencing, mating-type switching, gene conversion, cotranscriptional 3' processing of RNA polymerase II mRNA transcripts, and termination of RNA polymerase II transcription. Phenotypic associations include abnormal cell cycle progression, altered UV and X-ray resistance, decreased colony size, increased flocculation, abnormal telomere length, and reduced mating response. The gene is also connected to components of the Set1C and polyadenylation complexes, including SYC1, SHG1, and BRE2.