HSC82 — Schizosaccharomyces pombe 972h-

Summary

SPAC926.04C, symbol HSC82 and also known as hsp90 in Schizosaccharomyces pombe 972h- on chromosome 1, encodes an ATP-dependent protein folding chaperone belonging to the Hsp90 family, with ATP hydrolase activity and ATP binding. This gene is associated with a wide range of cellular processes including cell cycle control, sexual reproduction, mating type switching, chromatin silencing, nuclear division, gluconeogenesis, regulation of apoptotic process, and protein stabilization. It is linked to intracellular steroid hormone receptor signaling, adenylyl cyclase activation, cell motility, and Box C/D snoRNP assembly. Localization evidence connects the product to the perinuclear region of cytoplasm, mitochondria, plasmalemma, fungal-type cell wall, and extracellular vesicles. Phenotypic associations include increased thermotolerance, premature apoptosis, abnormal flocculation, decreased hypoosmotic stress resistance, altered cell cycle progression, and abnormal spore germination. Studies of related genes in other species link the family to amino acid and protein content traits.