ASPC — Schizosaccharomyces pombe 972h-

Summary

SPAC9G1.11C (symbol ASPC, also known as spn4 and CDC12) on chromosome 1 of Schizosaccharomyces pombe encodes a septin family protein with a G_SEPTIN domain and P-loop NTPase domain, possessing GTPase activity, GTP binding, phosphatidylinositol phosphate binding, and structural cytoskeletal constituent activity. The gene is associated with numerous cell cycle processes including cytokinesis, contractile ring assembly and contraction, actin filament capping and nucleation, septin ring organization and disassembly, spindle breakdown, and regulation of cell division and mitosis. It localizes to the septin cytoskeleton, septin complexes, and mating projection structures. Phenotypic associations include delayed cytokinesis, cell cycle arrest at anaphase and G2/M transition, absent cell fusion and chromosome segregation, abnormal bipolar budding, decreased redox state, increased anaerobic growth, and absent desiccation resistance. Studies of related genes in other species link the family to reduced virulence.