pka1 — Schizosaccharomyces pombe 972h-

Summary

SPBC106.10 (pka1) on chromosome 2 of Schizosaccharomyces pombe encodes a protein with a protein kinase domain, possessing protein serine/threonine kinase activity, cAMP-dependent protein kinase activity, PKC activity, ATP and zinc binding, and lipid binding, classified under EC 2.7.11.11. This gene is associated with adenylyl cyclase activation, glucose detection, regulation of response to osmotic stress, microtubule stabilization and destabilization, nucleus organization, regulation of cell division, and positive regulation of transcription by RNA polymerase III. It is linked to traits including calcium sensitivity and protein content, and phenotypes such as abnormal spore germination, altered cell size, decreased fermentative and respiratory metabolism, increased thermotolerance, reduced invasive and filamentous growth, and increased replicative lifespan. The protein localizes to the cAMP-dependent protein kinase complex, cytoskeleton, division septum, nucleoplasm, stress granules, and sites of polarized growth. Studies of related genes in other species link the family to reduced virulence.