imp2 — Schizosaccharomyces pombe 972h-

Summary

SPBC11C11.02 (imp2) on chromosome 2 of Schizosaccharomyces pombe encodes a protein with F-BAR and SH3 domains that exhibits peptidase inhibitor activity, PIP3 binding, cytoskeletal protein-membrane anchor activity, phosphatidylserine binding, phosphatidylinositol-4-phosphate binding, and phospholipid binding. The gene is associated with membrane tubulation, establishment of bipolar cell polarity, contractile ring contraction, abscission, mitotic actomyosin contractile ring contraction and assembly, vacuole fusion, clathrin-mediated endocytosis, intracellular transport, cell morphogenesis, cytoskeleton organization, cytokinesis, ubiquitin-dependent proteolysis, mitosis, secretion, and hypersensitivity. It localizes to the contractile actin ring, midsome, actomyosin contractile ring proximal layer, internal side of plasma membrane, medial membrane band, mitotic actomyosin contractile ring, actin patch, mating projection tip, endosome, and cell tip. Studies of related genes in other species link the family to cytokinesis and cell polarity.