ARK1 — Schizosaccharomyces pombe 972h-

Summary

ARK1 (tgp1) on chromosome 2 of Schizosaccharomyces pombe encodes a major facilitator superfamily (MFS) sugar transport-like protein with glycerol-3-phosphate, glycerophosphodiester, selenite:H+, manganese ion, phosphate, and carboxylic acid transmembrane transporter activities, as well as phosphate ion binding. The gene is associated with diverse biological processes including regulation of chromosome segregation, centrosome duplication, lncRNA transcription, TORC2 signaling, polyphosphate metabolism, intracellular phosphate homeostasis, and galactose-specific flocculation. It localizes to the plasma membrane, vacuolar membrane, and cell periphery. Phenotypic associations include decreased endocytosis, cytokinesis, and mating-type switching, delayed cell cycle progression in G2 phase, abnormal filamentous growth, and increased polyploidy. Related genes in other species are linked to cell membrane stability, protein content, and phosphate content.