MAP2 — Schizosaccharomyces pombe 972h-

Summary

SPBC14C8.03 (MAP2, fma2) in Schizosaccharomyces pombe 972h- on chromosome 2 encodes a methionyl aminopeptidase of the M24A family, possessing initiator methionyl aminopeptidase, metalloexopeptidase, and metalloaminopeptidase activities. The gene is associated with protein processing, proteolysis, translation initiation, cell cycle regulation including G1 phase and G2/M phase transition, mating and pheromone response, and cell division. It localises to the cytoplasm and cytosol. Phenotypic associations link MAP2 to abnormal cell size and shape, decreased colony size and exponential growth, altered budding patterns, increased chitin deposition, decreased alkaline pH and killer toxin resistance, increased resistance to enzymatic treatment, abnormal actin cytoskeleton and endoplasmic reticulum morphology, and premature cell cycle progression in metaphase and telophase. Related genes in other species connect the family to cell cycle control.