chp2 — Schizosaccharomyces pombe 972h-

Summary

SPBC16C6.10 (chp2) in Schizosaccharomyces pombe 972h- on chromosome 2 encodes a chromodomain-containing protein with histone H3K9me2/3 reader activity and chromatin adaptor, chromatin binding, identical protein binding, RNA binding and DNA binding activities. The protein localises to heterochromatin, including centric, subtelomeric and mating-type region heterochromatin, and to heterochromatin islands. It is associated with RNAi-mediated heterochromatin assembly at centromeres, siRNA-mediated silent mating-type cassette region heterochromatin formation, rDNA heterochromatin assembly, heterochromatin boundary formation, centromeric silencing, mitotic telomere tethering at the nuclear periphery, centromeric mitotic sister chromatin cohesion, anaphase cohesion protection, mitotic sister chromatid biorientation, spindle assembly checkpoint, mating-type switching, gene conversion at the mating-type locus, donor selection, sumoylation and demethylation. Studies of related genes in other species link the family to heterochromatin regulation.