cdc27 — Schizosaccharomyces pombe 972h-

Summary

SPBC1734.02C (cdc27) on chromosome 2 of Schizosaccharomyces pombe 972h- encodes a DNA-directed DNA polymerase, specifically the DNA polymerase delta subunit 3 (POLD3), a member of the POLD3_sf family. The gene product is associated with DNA replication elongation, including both leading and lagging strand elongation during mitosis, as well as strand displacement, nucleotide-excision repair DNA gap filling, and double-strand break repair. It is linked to cell cycle phases such as interphase, metaphase, and M phase, and to cellular responses to stress. The protein localises to the delta DNA polymerase complex, the nucleus, and the cytosol. Studies of related genes in other species connect the family to similar DNA replication and repair processes.