PRP2 — Schizosaccharomyces pombe 972h-

Summary

SPBC19C2.01 (symbol PRP2, also known as cdc28) on chromosome 2 of Schizosaccharomyces pombe encodes a DEAD/DEAH-box helicase with 3'-5' RNA helicase activity, ATP hydrolase activity, and binding to RNA, mRNA, double-stranded RNA, and the ribosomal small subunit. The protein localises to the spliceosome, nucleolus, and chromatin. It is associated with spliceosome disassembly, pre-RC assembly, mitotic metaphase and S phase, premeiotic DNA replication, chromosome separation, actin depolymerisation, septin checkpoint, and responses to UV and UV-A. Phenotypic associations include abnormal cell cycle progression through G2/M and S phase arrest, delayed chromosome segregation, increased X-ray resistance, altered mating efficiency and shmoo formation, abnormal carbon source utilisation, and defects in nuclear fusion, mating-type switching, and respiratory metabolism. Related genes in other species link the family to spliceosome remodelling.