ulp1 — Schizosaccharomyces pombe 972h-

Summary

SPBC19G7.09 (ulp1) on chromosome 2 of Schizosaccharomyces pombe encodes a SUMO-specific endopeptidase with deSUMOylase activity, belonging to the peptidase C48 family and the papain-like cysteine peptidase superfamily. The gene is associated with desumoylation and regulation of sumoylation, as well as centromere clustering, centromeric silencing, and localization to the nuclear periphery and nuclear envelope. It has been linked to cell cycle processes including mitosis, meiosis, S phase, anaphase, homologous recombination, DNA repair, and positive regulation of recombination-dependent DNA replication. Additional associations include protein processing, DNA anabolism, and cell growth. The product localizes to the nucleus, cytoplasm, and cytosol.