LEU2 — Schizosaccharomyces pombe 972h-

Summary

SPBC1A4.02C (LEU2, leu1) in Schizosaccharomyces pombe encodes a 3-isopropylmalate dehydrogenase (EC 1.1.1.85), an enzyme with isopropylmalate dehydrogenase and isocitrate/isopropylmalate dehydrogenase conserved domains that catalyses a step in L-leucine biosynthesis and requires NAD and magnesium. The gene is associated with L-leucine anabolism, the glyoxylate cycle, bioluminescence, RNA breakdown, tRNA processing, cell cycle control, homologous recombination, mating, cell growth, and digestion. It is linked to a wide range of phenotypes including decreased autophagy, increased mitotic recombination and mutation frequency, delayed cytokinesis and G1/S phase transition, decreased invasive and pseudohyphal growth, abnormal actin cytoskeleton morphology, decreased nutrient uptake and respiratory metabolism, increased small molecule transport, decreased nuclear export, and altered viability and survival. The protein localises to the cytosol.