HIS3 — Schizosaccharomyces pombe 972h-

Summary

SPBC21H7.07C (HIS3) on chromosome 2 of Schizosaccharomyces pombe encodes imidazoleglycerol-phosphate dehydratase (EC 4.2.1.19), an enzyme in histidine biosynthesis. The gene is associated with histidine anabolism, amino acid anabolism, and numerous cellular processes including cell cycle, mitosis, nuclear division, spindle assembly, homologous recombination, plasmid recombination, gene conversion, translation initiation and termination, mitochondrial translation, secretion, and protein transport. The product localises to the cytosol. Phenotypic associations include abnormal vegetative growth, decreased cell size, increased cell death, decreased ionic stress resistance, increased biofilm formation, increased filamentous growth, decreased acid pH resistance, decreased UV resistance, increased thermotolerance, decreased carbon source utilisation, and abnormal plasma membrane, endoplasmic reticulum, and nucleolar morphology. Studies of related genes in other species link the family to abnormal liquid culture appearance.