sfr1 — Schizosaccharomyces pombe 972h-

Summary

SPBC28F2.07 (sfr1) in Schizosaccharomyces pombe 972h- encodes a member of the SFR1/Mei5 protein family and exhibits ATPase activator activity, along with double-stranded and single-stranded DNA binding. The gene is associated with meiotic DNA recombinase assembly, reciprocal meiotic recombination, strand invasion, and resolution of recombination intermediates. It is linked to double-strand break repair during meiotic recombination, meiotic chromosome segregation, mating-type switching, and mitotic recombination. The product localizes to the nucleus, nuclear chromosome, mating-type region heterochromatin, and sites of double-strand breaks, as well as the cytosol. Related genes in other species are associated with the Sae3-Mei5 complex.