clr1 — Schizosaccharomyces pombe 972h-

Summary

SPBC2D10.17 (clr1) in Schizosaccharomyces pombe 972h- on chromosome 2 encodes a zinc-binding protein with a Znf_C2H2-type domain. The gene is associated with chromatin silencing, including centromeric, telomeric, and silent mating-type cassette silencing, as well as rDNA heterochromatin assembly and chromatin organization. It is linked to mating-type switching, donor selection, gene conversion, DNA replication and repair, S phase, methylation, and PTGS. The product localizes to the nucleus, subtelomeres, centric heterochromatin, mating-type region heterochromatin, and rDNA heterochromatin. Related genes in other species are associated with the SHREC complex.