TOR — Schizosaccharomyces pombe 972h-

Summary

SPBC30D10.10C (tor1, TOR) in Schizosaccharomyces pombe 972h- encodes a serine/threonine-protein kinase with histone H2A kinase activity, classified as EC 2.7.11.1. The protein contains FRB, FAT, FATC, and PI3/4-kinase catalytic domains, and is a component of TOR complex 1 (TORC1), the ATR-ATRIP complex, and the Tor2-Mei2-Ste11 complex. It localizes to nucleolar chromatin, perinuclear cytoplasm, and telomeric chromosome regions. The gene is associated with carbohydrate and glucose homeostasis, calcium ion homeostasis, cell quiescence, reversible differentiation, contractile ring contraction, mitochondrial depolarization, tRNA transcription, and regulation of double-strand break repair. Phenotypic associations include abnormal cell cycle progression through G1/S phase transition, absent sporulation efficiency, increased virulence, decreased polyploidy, and altered carbon and nitrogen source utilization.