fbh1 — Schizosaccharomyces pombe 972h-

Summary

SPBC336.01 (fbh1) in Schizosaccharomyces pombe 972h- on chromosome 2 encodes a protein with a UvrD-like DNA helicase domain and an F-box domain, giving it both single-stranded 3'-5' DNA helicase activity (EC 5.6.2.4) and ubiquitin ligase substrate adaptor function. It also binds ATP and ssDNA. The gene is associated with meiotic cell cycle control, regulation of DNA recombination, meiotic prophase I, resolution of meiotic recombination intermediates, replication fork arrest, mitotic recombination-dependent replication fork processing, gene conversion, recombinational repair, meiotic chromosome segregation, SCF-dependent proteasomal ubiquitin-dependent protein breakdown, spore germination, and homologous recombination repair. It localises to the nucleus, cytosol, ssDNA-dependent ATP-dependent DNA helicase complex, and nuclear SCF complex.