ARK1 — Schizosaccharomyces pombe 972h-

Summary

SPBC36.03C (ARK1, also known as mfs3) on chromosome 2 of Schizosaccharomyces pombe encodes an uncharacterized transporter of the major facilitator superfamily (MFS). The gene product is annotated with xenobiotic, spermidine, spermine, and transmembrane transporter activities, and is associated with the transport of putrescine, spermidine, fluconazole, and peptides. ARK1 has been linked to numerous cellular processes including regulation of chromosome segregation, centrosome duplication, kinetochore assembly, sister chromatid segregation, chromosome condensation and biorientation, telophase, meiosis II, microtubule shortening, TORC2 signaling, and cellular homeostasis. It localizes to the plasma membrane, fungal-type vacuole membrane, Golgi, and ER. Phenotypic associations include delayed cell cycle progression in G2 phase, decreased endocytosis, altered filamentous growth, increased polyploidy, and reduced chemical resistance. Studies of related genes in other species link the family to reduced virulence.