dcp1 — Schizosaccharomyces pombe 972h-

Summary

SPBC3B9.21 (dcp1) on chromosome 2 of Schizosaccharomyces pombe 972h- encodes a Dcp1 family protein with a PH-like domain superfamily fold and mRNA phosphatase activator activity, as well as RNA binding. The gene is associated with RNA decapping, specifically mRNA methylguanosine-cap decapping, and with deadenylylation-dependent decapping, nonsense-mediated mRNA decay, nuclear mRNA breakdown, and RNA surveillance. It is linked to P body assembly and localises to the P body, stress granule, cytosol, and nucleus, and is also associated with the Dcp1-Dcp2 complex. Additional associations include mRNA stabilization and cellular homeostasis.