SLP1 — Schizosaccharomyces pombe 972h-

Summary

SPBC3E7.09 (SLP1) on chromosome 2 of Schizosaccharomyces pombe encodes a SUN-like protein 1, a member of the Suco/Slp1 family containing a SUN domain. This gene is associated with multiple cell cycle processes, including the meiosis I/meiosis II transition, activation of meiosis, mitotic anaphase, and the spindle assembly checkpoint. It is also linked to response to radiation, centromere localization, protein folding in the endoplasmic reticulum, and deubiquitination. The protein localizes to the ER membrane, membrane, and cytoplasm. Phenotypic associations include abnormal nuclear fusion during mating, cell cycle arrest in metaphase, increased UV resistance, decreased autophagy and ribophagy, altered protein secretion and transport, abnormal spindle morphology, and increased sporulation efficiency. Studies of related genes in other species link the family to phosphate content and interactions with MNL1, ALG3, SSM4, and CDC48.