MCM2 — Schizosaccharomyces pombe 972h-

Summary

SPBC4.04C, designated mcm2 (MCM2) on chromosome 2 of Schizosaccharomyces pombe 972h-, encodes an MCM family protein with ATP hydrolase activity (EC 3.6.4.12) and DNA helicase activity. The product has H3-H4 histone carrier activity, binds DNA replication origins, nucleosomes, chromatin, single-stranded DNA, and zinc, and localizes to the MCM complex, nuclear pre-replicative complex, pre-initiation complex, heterochromatin, telomeric regions, and replication forks. MCM2 is associated with MCM complex assembly, mitotic and premeiotic DNA replication, replication licensing, DNA replication elongation, checkpoint control, double-strand break repair via break-induced replication, recombinational repair, replication-dependent chromatin assembly, and the response to hydroxyurea. Phenotypic associations link the gene to cell cycle progression through G1/S and G2/M transitions, S phase duration, mitotic recombination, mating-type switching, transposable element transposition, gamma ray resistance, vegetative growth, sporulation, chronological lifespan, chromosome segregation, meiotic recombination, and necrotic cell death.