ATG5 — Schizosaccharomyces pombe 972h-

Summary

SPBC4B4.10C (ATG5) in Schizosaccharomyces pombe encodes a protein with APG8 ligase activity, belonging to the ATG5_HBR and Atg5_HR domain families. It is a core component of the Atg12-Atg5-Atg16 complex and localises to the phagophore assembly site (PAS), phagophore membrane, cytosol, nucleus, and mitochondria-associated membranes. The gene is associated with autophagy, including macroautophagy, mitophagy, aggrephagy, ER-phagy, and nucleophagy, as well as cellular responses to nitrogen starvation, vacuole fusion, protein transport, mating, and the meiotic cell cycle. Phenotypic associations link ATG5 to delayed autophagy and chemical compound accumulation, absent cell cycle progression, abnormal pseudohyphal and filamentous growth, decreased ribophagy and pexophagy, increased mating response and mitochondrial mutation frequency, and altered protein secretion and vacuolar transport.