NIME — Schizosaccharomyces pombe 972h-

Summary

SPBC582.03, also known as NIME or cdc13 in Schizosaccharomyces pombe 972h- on chromosome 2, encodes a cyclin A/B-like protein. The product has cyclin-dependent protein serine/threonine kinase activator and regulator activities, and is associated with protein kinase activity. This gene is linked to cell cycle processes including mitotic S phase, G1/S phase transition, regulation of CDK activity, and cell division. It is also connected to telomere localization and capping, bipolar cell growth, response to caffeine, negative regulation of ascospore formation and meiotic cell cycle, and second meiotic division. The protein localizes to the CDK holoenzyme, mitotic and meiotic spindles, microtubule organizing centers, and telomeric regions. Associations include decreased vegetative growth, reduced replicative and chronological lifespan, and abnormal mitochondrial genome maintenance.