nbs1 — Schizosaccharomyces pombe 972h-

Summary

SPBC6B1.09C (nbs1) in Schizosaccharomyces pombe 972h- on chromosome 2 encodes a nibrin-related protein containing FHA and BRCT domains, functioning in phosphorylation-dependent protein binding, damaged DNA binding, and as a chromatin adaptor and bridging factor. It is a component of the MRN complex and localises to the nucleus, telomeric repeat regions, and sites of double-strand breaks. The gene is associated with DNA double-strand break processing, meiotic DNA double-strand break formation, recombinational repair, non-homologous end joining, nucleotide excision repair, gene conversion, telomere maintenance via recombination, and cell cycle checkpoints including mitotic G2, intra-S, and DNA replication checkpoints. It is also linked to response to bleomycin and hydroxyurea, protein positioning, prophase, M phase, G1 phase, and DNA anabolism.