MBP1 — Schizosaccharomyces pombe 972h-

Summary

SPBC725.16 (MBP1, also known as res1) on chromosome 2 of Schizosaccharomyces pombe encodes a protein with SWI6-like and APSES-type helix-turn-helix domains, including ankyrin repeats, and is associated with DNA-binding transcription repressor, activator, and coactivator activities specific to RNA polymerase II. The gene is associated with regulation of the mitotic and meiotic cell cycles, including G1, S, G2, and M phases, as well as DNA replication, mating, conidia formation, and melanin and steroid metabolism. It localizes to the nucleus, cytoplasm, chromatin, and the MBF and SBF complexes. Phenotypic associations link MBP1 to cell cycle progression through Start, mating efficiency, pheromone sensitivity, gamma ray resistance, chronological lifespan, telomere length, and vegetative growth. Studies of related genes in other species connect the family to germination rate, protein content, and reduced virulence.