HH3 — Schizosaccharomyces pombe 972h-

Summary

SPBC8D2.04, also known as HH3 or hht2, encodes a histone H3/CENP-A family protein in Schizosaccharomyces pombe 972h- on chromosome 2. The product is a structural constituent of chromatin, binds nucleosomal DNA, and exhibits protein heterodimerization activity. This gene is associated with centromere localization, kinetochore assembly, mitotic metaphase chromosome alignment, and sister chromatid biorientation. It is linked to heterochromatin boundary formation, centromeric silencing, and mating-type switching. The protein localizes to the nucleosome, kinetochore, and various heterochromatin regions including subtelomeric and centric heterochromatin. Phenotypic associations include altered cell cycle progression through S phase, metaphase, and anaphase, as well as changes in sporulation rate, meiosis timing, and resistance to gamma rays and hypoosmotic stress. The gene is also associated with DNA damage response, DNA replication, and proteolysis.