DBP2 — Schizosaccharomyces pombe 972h-

Summary

SPBCPT2R1.08C (DBP2, tlh2) on chromosome 2 of Schizosaccharomyces pombe encodes a DEAD/DEAH-box helicase with four-way junction helicase activity, 3'-5' DNA helicase activity, and RNA helicase activity. The gene is associated with resolution of recombination intermediates, meiotic prophase I, alternative mRNA splicing via the spliceosome, and nonsense-mediated mRNA decay. It is linked to response to UV and UV-A, replication fork arrest, DNA double-strand break processing, and rDNA maintenance. The protein localizes to the RecQ helicase-Topo III complex, nuclear replication forks, and telomeric repeat regions. Phenotypic associations include abnormal mitotic recombination, decreased mating-type switching, absent sporulation efficiency, increased thermotolerance, increased gamma ray resistance, delayed vegetative growth, and altered cell cycle progression through G1/S and G2/M phase transitions.