mit1 — Schizosaccharomyces pombe 972h-

Summary

SPBP35G2.10 (mit1) on chromosome 2 of Schizosaccharomyces pombe 972h- encodes a protein with ATP-dependent chromatin remodeler activity, DNA translocase activity, helicase activity, histone carrier activity, and H3-H4 dimer loading activity. The protein contains SNF2, PHD-finger, chromo, and CCCH zinc-finger domains. Mit1 is associated with constitutive heterochromatin assembly, transposable element silencing, post-transcriptional gene silencing, heterochromatin boundary formation, rDNA heterochromatin assembly, attachment of telomeric heterochromatin to the nuclear envelope, DNA double-strand break processing, nucleosome organization and disassembly, co-transcriptional chromatin reassembly, CENP-A containing chromatin assembly, transcription-coupled nucleotide excision repair, cellular pheromone response, and cellular response to copper. It localizes to heterochromatin, CHRAC, SWI-SNF and PBAF complexes, nuclear microtubules, and centromeric regions. Related genes in other species are linked to SHREC complex localization.