pho1 — Schizosaccharomyces pombe 972h-

Summary

SPBP4G3.02 (symbol pho1) on chromosome 2 of Schizosaccharomyces pombe 972h- encodes a histidine acid phosphatase belonging to the His_PPase superfamily, with 4-phytase, 3-phytase, thiamin monophosphatase, inositol phosphate phosphatase, and general acid phosphatase activities (EC 3.1.3.2). The gene is associated with cellular response to phosphate starvation, phosphate and polyphosphate metabolism, inositol phosphate metabolism, organophosphate breakdown, thiamin metabolism and salvage, and thiamin biosynthesis. It has also been linked to vacuole fusion, cytokinesis, chromatin silencing, RNA processing, the glucose effect, and response to nutrient levels. The product localises to the cell wall-bounded periplasmic space, the fungal-type cell wall, the cytoplasm, and the extracellular space. Related genes in other species are linked to reduced virulence and disseminated candidiasis.