GAL2 — Schizosaccharomyces pombe 972h-

Summary

SPCC1235.14, also known as GAL2 or ght5, encodes a hexose transmembrane transporter belonging to the MFS sugar transporter family, with high-affinity glucose:proton symporter activity and the ability to transport galactose and gluconate across the plasma membrane. In Schizosaccharomyces pombe, this gene is associated with glucose homeostasis, TORC2 signaling, carbohydrate transport, fermentation, endocytosis, vacuolar transport, and cell cycle control. Phenotypic associations link GAL2 to increased nutrient uptake and carbon source utilization, altered spore germination and sporulation, increased endocytosis and anaerobic growth, abnormal bipolar budding and pseudohyphal growth, increased freeze-thaw resistance, and decreased entry into stationary phase. The protein localizes to the plasma membrane, cell tip, cell division site, vacuole, and mitochondrial membrane. Studies of related genes in other species connect the family to sugar transport and stress responses.