ctr4 — Schizosaccharomyces pombe 972h-

Summary

The Schizosaccharomyces pombe gene ctr4 (SPCC1393.10) on chromosome 3 encodes a copper transporter family protein (Cop_transporter domain) with copper ion transmembrane transporter activity. It is associated with copper ion import and export, response to copper, and cellular localization to the plasma membrane and fungal-type vacuole. The gene is linked to iron transport, cell cycle control, mating, meiosis, mitosis, spore germination, and detoxification. Traits associated with ctr4 include copper concentration and sensitivity, acid sensitivity, and oxidative stress response. Phenotypic associations include altered alkaline pH resistance, respiratory growth, sporulation efficiency, vegetative growth, competitive fitness, and increased heat sensitivity, as well as decreased UV resistance, desiccation resistance, and chronological lifespan. Studies of related genes in other species link the family to reduced virulence.