MCM4 — Schizosaccharomyces pombe 972h-

Summary

SPCC16A11.17 (MCM4) in Schizosaccharomyces pombe 972h- encodes a member of the MCM family with ATP hydrolase and DNA helicase activities (EC 3.6.4.12). The product also exhibits H3-H4 histone carrier activity, nucleosome and chromatin binding, and DNA replication origin binding. MCM4 is associated with mitotic and premeiotic DNA replication, replication initiation and elongation, double-strand break repair via break-induced replication, and DNA damage checkpoint responses. It localises to the MCM complex, nuclear pre-replicative complex, replication forks, heterochromatin, and telomeric regions. Phenotypic associations link MCM4 to cell cycle progression, including increased G1 phase rate, delayed G2 phase, and decreased S phase progression, as well as altered gamma ray resistance, sporulation, meiotic recombination, telomere length, and chronological lifespan. Related genes in other species connect it to replication licensing factors and helicases.