git3 — Schizosaccharomyces pombe 972h-

Summary

SPCC1753.02C (git3) on chromosome 3 of Schizosaccharomyces pombe encodes a G protein-coupled glucose receptor, belonging to the Glucose_rcpt_Git3_N domain family. The gene product has G protein-coupled glucose receptor activity and GPCR activity. It is associated with glucose detection, the glucose-sensing PKA pathway, adenylyl cyclase activation, and protein kinase A activation. Additional associations include regulation of glucose detection, response to glucose, GMP anabolism, and the adenylate cyclase-activating GPCR signaling pathway. The protein localises to the plasmalemma. Git3 is also linked to kinetochore assembly, mitochondrial fission, intracellular transport, cytokinesis, meiosis, mitosis, vacuolar acidification, and pH reduction. A trait association with respiration rate, measured as CO2 output, has been noted. Studies of related genes in other species link the family to glucose sensing.