wee1 — Schizosaccharomyces pombe 972h-

Summary

SPCC18B5.03, also known as wee1, on chromosome 3 of Schizosaccharomyces pombe 972h-, encodes a non-membrane spanning protein tyrosine kinase with EC 2.7.10.2 activity. The product possesses protein serine/threonine kinase activity, microtubule binding, and histone kinase activities including H2BS14 and H3S10. This gene is associated with negative regulation of the cell cycle, particularly the G2/M transition of the meiotic cell cycle, downregulation of mitosis and phosphorylation, and DNA integrity checkpoint processes. It has been linked to root morphogenesis, endosperm development, pollination, embryogenesis, cell tip growth, and responses to ethylene, hydrostatic pressure, and radiation. The protein localizes to the mitotic and meiotic spindle midzone, spindle microtubules, inner kinetochore, septin ring, and CPC complex.