PHOD — Schizosaccharomyces pombe 972h-

Summary

SPCC2H8.02 (PHOD, SpPHOD) on chromosome 3 of Schizosaccharomyces pombe encodes a member of the major facilitator superfamily (MFS) of sugar transporters, specifically a phosphate permease. The protein possesses glycerol-3-phosphate, glycerophosphodiester, selenite:H+, manganese ion, and phosphate transmembrane transporter activities, and binds phosphate ions. It is associated with phosphate homeostasis, polyphosphate metabolism, glycerophosphodiester transport, selenite transport, and responses to nutrients. The gene is linked to numerous cellular processes including cell cycle progression, vacuolar and Golgi distribution, biofilm formation, spore germination, fermentative and anaerobic growth, desiccation and freeze-thaw resistance, mitophagy, and survival in stationary phase. It localizes to the plasma membrane, vacuolar membrane, Golgi membrane, and endoplasmic reticulum. Studies of related genes in other species connect the family to phosphate content, sodium content, and calcium sensitivity.