RAD16 — Schizosaccharomyces pombe 972h-

Summary

SPCC330.01C, also known as RAD16 or rhp16 on chromosome 3 of Schizosaccharomyces pombe 972h-, encodes a protein with a SNF2/RAD54 helicase domain and a RING-type zinc finger, conferring ATP-dependent chromatin remodeller activity, helicase activity, damaged DNA binding, and ubiquitin ligase activity. The gene is associated with nucleotide-excision repair, including global genomic and transcription-coupled repair, interstrand crosslink repair, replication fork reversal, recombinational repair, and the DNA integrity checkpoint. It is linked to mating-type switching, transposition, and gene conversion, and localises to chromatin, the nucleus, and sites of double-strand breaks. Phenotypic associations include decreased ionizing radiation resistance, increased mutation frequency, abnormal meiotic recombination, delayed cell cycle progression, increased silencing, and altered fermentative and respiratory growth. Related genes in other species link the family to similar DNA repair and chromatin remodelling functions.