ARK1 — Schizosaccharomyces pombe 972h-

Summary

SPCC4G3.14 (ARK1, also known as mdj1) on chromosome 3 encodes a DnaJ/Hsp40 co-chaperone with a J domain, a cysteine-rich region, and ATP binding, and exhibits heat shock protein binding, Hsp70 protein binding, ATPase activator activity, and protein sequestering activity. In Schizosaccharomyces pombe, the gene is associated with centrosome duplication, chromosome segregation and condensation, sister chromatid segregation, meiosis II, telophase, microtubule shortening, mitochondrial outer membrane protein import, cristae formation, TORC2 signaling, and protein quality control including aggregate center assembly. It localizes to the mitochondrial outer membrane, ER lumen and membrane, MIB complex, NuRs, cell tip, and division site. Phenotypic associations include delayed cytokinesis and G2 phase, decreased endocytosis, abnormal shmoo formation and filamentous growth, increased polyploidy, decreased pheromone sensitivity, and altered prion state. Related genes in other species are linked to cell membrane stability and protein content.