ARK1 — Schizosaccharomyces pombe 972h-

Summary

SPCC569.05C (ARK1, also known as SpARK1 or SpPRK1) on chromosome 3 of Schizosaccharomyces pombe encodes an uncharacterized transporter belonging to the major facilitator superfamily (MFS). The gene product is associated with xenobiotic, spermidine, spermine, and transmembrane transporter activities, as well as putrescine, peptide, spermidine, and fluconazole transport. ARK1 is linked to regulation of chromosome segregation, centrosome duplication, centromere localization, chromosome biorientation, sister chromatid segregation, chromosome condensation, kinetochore assembly, telophase, and meiosis II. It is also associated with TORC2 signaling, microtubule shortening, cellular homeostasis, and protein positioning. The protein localizes to the cellular bud membrane, fungal-type vacuole and its membrane, Golgi complex, endoplasmic reticulum, and plasmalemma. Phenotypic associations include decreased rates of cytokinesis, endocytosis, and bipolar budding, delayed G2 phase progression, increased polyploidy, and abnormal filamentous growth.