TSA1 — Schizosaccharomyces pombe 972h-

Summary

SPCC576.03C (TSA1, tpx1) on chromosome 3 of Schizosaccharomyces pombe encodes a peroxiredoxin with thioredoxin-dependent peroxidase activity (EC 1.11.1.24), also annotated with protein-disulfide reductase and MAP kinase scaffold activities. The product is a member of the AhpC/TSA and thioredoxin-like families and localises to the cytoplasm, nucleus and cell wall. TSA1 is associated with cellular redox homeostasis, response to hydrogen peroxide and oxidative stress, activation of the p38 cascade, DNA replication checkpoint control, and filamentous growth in response to starvation or chemical stimuli. Phenotypic associations link the gene to oxidative stress resistance, cell cycle progression through G2/M and S phases, mitotic and meiotic recombination, chromosome segregation, apoptosis, adhesion, pexophagy, and UV resistance. Related genes in other species connect the family to oxidative stress response.