SMC6 — Schizosaccharomyces pombe 972h-

Summary

SPCC5E4.06, designated SMC6 in Schizosaccharomyces pombe 972h- on chromosome 3, encodes a protein with RecF/RecN/SMC_N and P-loop_NTPase domains and ATPase activity acting on DNA, along with damaged DNA and single-stranded DNA binding. The protein localises to the Smc5-Smc6 complex, spindle pole body, sites of double-strand breaks, division septum, telomeric chromosome regions and the nucleus. SMC6 is associated with meiotic prophase I, telomere maintenance regulation, chromosome condensation and looping, replication fork arrest, recombinational repair, base excision repair, mismatch repair, nucleotide excision repair, sumoylation, mitotic chromosome segregation, and DNA damage tolerance. Phenotypic associations include abnormal sporulation efficiency, altered cell cycle progression, increased thermotolerance and gamma ray resistance, decreased lifespan, absent meiotic recombination, delayed vegetative growth, and abnormal telomere length. Related genes in other species are linked to chromosome segregation and cell cycle progression.