TIP1 — Schizosaccharomyces pombe 972h-

Summary

SPCC61.04C (TIP1) in Schizosaccharomyces pombe 972h- encodes a Yip1/4-like family protein with a Yip1 domain and is annotated to small GTPase binding. The gene is associated with microtubule-based transport, microtubule stabilization and dynamics, vesicle fusion with the Golgi apparatus, prenylation, cell polarity maintenance, spindle elongation, cell cycle checkpoints, and nuclear movement. It localizes to the trans-Golgi network, Golgi membrane, and ER membrane. Phenotypic associations include abnormal protein transport, Golgi distribution and morphology, endocytosis, cytokinesis, cell death, and cytoskeleton morphology; increased UV and ionic stress resistance; and altered autophagy, mating response, and nutrient uptake. Related genes in other species link the family to intracellular transport and Golgi function.