epe1 — Schizosaccharomyces pombe 972h-

Summary

SPCC622.16C (epe1) on chromosome 3 of Schizosaccharomyces pombe encodes a JmjC domain-containing histone demethylase with EC 1.14.11.27 activity, functioning as a histone H3K36me/H3K36me2 demethylase, histone H3K9 demethylase, and histone H3K4me3 reader, and also possessing DNA-binding transcription factor activity specific to RNA polymerase II. The gene is associated with oxidative demethylation, activation of RNAi, RNA-directed DNA methylation (RdDM), regulation of RNAi-mediated heterochromatin assembly, heterochromatin boundary formation, positive regulation of transcription elongation by RNA polymerase II, pigment accumulation, memory, RNA surveillance, and nuclear import. It localizes to heterochromatin islands, subtelomeric heterochromatin, centric heterochromatin, and the mating-type region heterochromatin.