LSP1 — Schizosaccharomyces pombe 972h-

Summary

SPCC736.15, also known as pil1 or LSP1 in Schizosaccharomyces pombe 972h- on chromosome 3, encodes a protein belonging to the PIL1/LSP1 family and the AH/BAR domain superfamily, with lipid-binding molecular function. The gene is associated with eisosome assembly, plasma membrane organization, endocytosis, cytokinesis, cell motility, signal transduction, MAPK cascade, rRNA transcription and processing, sporulation, morphogenesis, and homeostasis. It localizes to the eisosome, plasma membrane, nuclear membrane, ascus membrane, prospore membrane leading edge, and meiotic spindle pole body. Phenotypically, the gene is linked to abnormal cell cycle progression, decreased cytokinesis and endocytosis rates, absent cell fusion and meiosis, abnormal shmoo formation and filamentous growth, increased necrotic cell death, and altered pheromone sensitivity and prion inheritance. Studies of related genes in other species connect the family to linear eisosome organization.