CSB — Schizosaccharomyces pombe 972h-

Summary

SPCP25A2.02C (SpCSB, also known as rhp26) on chromosome 3 of Schizosaccharomyces pombe encodes a SNF2/RAD54-family helicase with ATP-dependent chromatin remodeler activity, histone octamer slider activity, nucleosome array spacer activity, DNA translocase activity, and TBP-class protein binding. The gene is associated with global genome repair (GGR), DNA integrity checkpoint control, double-strand break repair via synthesis-dependent strand annealing, meiotic gene conversion, gene conversion at the mating-type locus, nucleosome disassembly and organization, spindle pole body separation, microtubule destabilization and bundling, cell cycle phase regulation, and negative regulation of antisense RNA transcription. Phenotypic associations include absent mating-type switching, absent meiotic recombination, absent UV resistance, decreased radiation resistance, decreased ribophagy, abnormal mutation frequency, abnormal telomere length, abnormal pheromone sensitivity and shmoo formation, delayed exponential-phase growth, and sterile phenotype.