GAP1 — Schizosaccharomyces pombe 972h-

Summary

SPAC1039.09, also known as GAP1 or isp5, encodes an amino acid permease with L-arginine and L-lysine transporter activity, belonging to the APC/YAT family. The gene is associated with the transport of basic amino acids, including L-lysine, L-arginine, and L-leucine import into cells. It has been linked to cell-cell fusion, regulation of growth and cytokinesis, Ras protein signal transduction, replication fork arrest, nucleosome assembly, and cellular response to stress. The protein localizes to the plasma membrane, cell tips, Golgi membrane, fungal-type vacuole, and cell division sites. Phenotypic associations include altered nutrient uptake, endocytosis, sporulation, cell cycle progression, hydrostatic pressure resistance, and carbon and nitrogen source utilization. Studies of related genes in other species connect the family to oxidative stress response and phosphate content.