RSP5 — Schizosaccharomyces pombe 972h-

Summary

SPAC11G7.02, also known as RSP5 or pub1 in Schizosaccharomyces pombe 972h- on chromosome 1, encodes a HECT-type E3 ubiquitin-protein ligase (EC 2.3.2.26) with C2 and WW domains, conferring ubiquitin-protein transferase and phospholipid binding activities. This gene is associated with protein ubiquitination, ubiquitin-mediated endocytosis, vacuolar transport, and protein localization to the vacuole, as well as TORC2 signaling, cell cycle control, cytokinesis, and DNA damage checkpoint processes. It is linked to regulation of cell growth, amino acid import, dephosphorylation, and deubiquitination. Phenotypic associations include abnormal nitrogen source utilization, altered cell cycle progression through G2/M phase, decreased cytokinesis rate, delayed exponential growth, reduced hypoosmotic stress resistance, increased endocytosis, and abnormal Golgi distribution. The gene localizes to the cell periphery, Golgi complex, membrane, and cytoplasm.