SNF2 — Schizosaccharomyces pombe 972h-

Summary

SPAC1250.01 (SNF2, snf21) on chromosome 1 of Schizosaccharomyces pombe encodes a protein with ATP-dependent chromatin remodeler activity, histone octamer slider activity, nucleosome array spacer activity, DNA translocase activity, helicase activity, and histone binding. It is associated with nucleosome organization and disassembly, meiotic prophase I, transposable element silencing, heterochromatin boundary formation, kinetochore assembly, and the spindle checkpoint. The gene is linked to the SHREC and PBAF complexes, CENP-A-containing chromatin, and heterochromatin islands. Phenotypic associations include abnormal cell fusion, increased thermotolerance, increased transposable element transposition, delayed carbon source utilization, and premature cell cycle progression through G1/S and G2/M transitions. Related genes in other species link it to the SWI-SNF complex and oxidative stress response.