DDP1 — Schizosaccharomyces pombe 972h-

Summary

SPAC13G6.14 (symbol DDP1, preferred name aps1) on chromosome 1 of Schizosaccharomyces pombe 972h- encodes a NUDIX hydrolase domain-containing protein with diphosphoinositol-polyphosphate diphosphatase, AP5A and AP6A hydrolase, and inositol phosphate phosphatase activities (EC 3.6.1.52). The gene is associated with diadenosine polyphosphate and inositol phosphate catabolism, heterochromatin organization, lncRNA transcription, intracellular phosphate homeostasis, signal transduction, mating, and chromosome division. It localizes to the cytoplasm, cytosol, and nucleus. Phenotypic associations include altered pseudohyphal and invasive growth, increased hyperosmotic stress resistance, decreased telomere length and sporulation, increased transposable element transposition and mutation frequency, abnormal actin cytoskeleton and mitochondrial morphology, and increased cell size.