hal3 — Schizosaccharomyces pombe 972h-

Summary

SPAC15E1.04 (hal3, also known as SpCDC21 or CDC21) on chromosome 1 of Schizosaccharomyces pombe encodes a protein with thymidylate synthase activity (EC 2.1.1.45), phosphopantothenoylcysteine decarboxylase activity, and protein phosphatase inhibitor activity, and contains a thymidylate synthase domain and a flavoprotein domain with FMN binding. The gene is associated with dTTP and dTMP anabolism, CoA biosynthesis, regulation of K+ transport, and DNA replication initiation, as well as G2 phase, meiosis II, and mitotic recombination. It is linked to potassium concentration, and to phenotypes including abnormal cell cycle progression, increased mutation frequency, altered chitin deposition, and abnormal nuclear morphology. The gene product localizes to the nucleus, cytosol, mitochondria, and nuclear periphery. Studies of related genes in other species link them to cell cycle arrest and decreased viability.