URA4 — Schizosaccharomyces pombe 972h-

Summary

SPAC16.03C (URA4, ura2) on chromosome 1 of Schizosaccharomyces pombe 972h- encodes a dihydroorotase, classified as EC 3.5.2.3, with dihydroorotase activity and metal binding. The product belongs to the amidohydrolase-related family and contains a dihydroorotase conserved sequence domain. This gene is associated with de novo UMP biosynthesis, pyrimidine nucleotide anabolism, and uracil anabolism. It has also been linked to plasmid recombination, telomere assembly, regulation of mitotic recombination, downregulation of mitosis, G2 phase, mtDNA replication, response to MMS, cellular homeostasis, structural organization, galactose metabolism, ubiquinone anabolism, and blood clotting. The protein localizes to both the cytoplasm and nucleus. Studies of related genes in other species connect the family to oxidative stress response, heat sensitivity, desiccation resistance, metal resistance, competitive fitness, vegetative growth rate, vacuolar morphology, and chemical resistance.